A nutrient commonly depleted by medications is CoQ10. With Lipitor® being the leading selling prescription drug in the United States, one can see why. Lipitor® (Atorvastatin) along with Zocor® (Simvastatin), Mevacor® (Lovastatin), Pravachol® (Pravastatin), Lescol® (fluvastatin), Crestor® (rosuvastatin), and Vytorin® (ezetimibe/simvastatin), also known as HMG-CoA reductase inhibitors or statin drugs, decrease the production of cholesterol, but they also decrease this very important cofactor naturally produced by the body. Other medications have also been implicated in CoQ10 depletion.
CoQ10 is necessary for the production of ATP (adenosine triphosphate), which makes energy, is a cofactor necessary for cellular respiration, and an antioxidant.
Some of the consequences of CoQ10 depletion include:
- Muscle weakness
- Cardiovascular disease
- Periodontal disease
- Weakened immunity
- Loss of cognitive function (Alzheimers, Dementia, Parkinsons)
There are many animal and human studies demonstrating the effectiveness of this coenzyme. A double-blind, three-year trial involved administering 100 mg of CoQ10 daily to patients suffering from cardiomyopathy. Results showed a significant increase in ejection fraction (the amount of blood pumped through the heart), increased cardiac muscle strength, and fewer instances of shortness of breath by the 12-week mark. The effects lasted only as long as CoQ10 was being administered. There was 89% improvement in the 80 patients treated.
A direct correlation of CoQ10 deficiency with increased risk of periodontal disease has been established. Symptoms include swelling, bleeding, loose teeth, redness, pain, deep gingival pockets, and exudates.
Tissues involved with immune function require a significant amount of energy. CoQ10 has an “immune enhancing” effect on the human body according to a study that showed an increased immunoglobulin G in the serum of patients taking the nutritional supplement daily for 27 to 98 days. Improving immune function is necessary when treating AIDS, chronic infections (Candidiasis), and cancer. There are no adverse interactions between CoQ10 and any other drug or nutrient.
CoQ10 is typically dosed at 50-300 mg/day, although doses of over 3,000 mg daily have been proven safe and effective. It works very well in conjunction with vitamin E and L-carnitine.